Clinical Podcasts

UpToDate faculty discuss important “What’s New” and “Practice Changing UpDates”, based on recent medical journal articles, in our clinical podcasts. Our contributors are recognized physician leaders in their fields and offer their expertise regarding each update and its impact on clinical practice. Each clinical podcast includes the most current clinical information available as of the release date listed.

Support for UpToDate Talk is provided by UpToDate, Wolters Kluwer. UpToDate is entirely funded by the subscriptions of its users and does not accept advertising or funding unrelated to subscriptions. The opinions in such podcasts are entirely those of the discussants, and these discussants are authors and editors for UpToDate. View the UpToDate conflict of interest policy.

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Adverse pregnancy outcomes associated with treatment for CIN; Prevention of egg allergy in infants

Date Released: 2月 22 2017

This episode features Dr. Barbara Goff, discussing a population-based study on adverse pregnancy outcomes associated with treatment for cervical intraepithelial neoplasia (CIN) (starts at 00:43); and Dr. David Fleischer, discussing data on early dietary egg introduction for the prevention of egg allergy in infants (starts at 15:32).

Listen to the full podcast by pressing the Play Button below, or jump to the segment on adverse pregnancy outcomes associated with treatment for CIN, or the segment on prevention of egg allergy in infants.

Dr. GoffDr. Barbara Goff is a Professor of Obstetrics and Gynecology and Director of the Division of Gynecologic Oncology at the University of Washington School of Medicine.
Dr. FleischerDr. David Fleischer is an Associate Professor of Pediatrics and Allergy at the University of Colorado School of Medicine and Director of the Food Challenge Unit at Children’s Hospital Colorado.

Segment on adverse pregnancy outcomes associated with treatment for CIN (Dr. Goff):

  1. Bjørge T, Skare GB, Bjørge L, et al. Adverse Pregnancy Outcomes After Treatment for Cervical Intraepithelial Neoplasia. Obstet Gynecol 2016; 128:1265.

Segment on prevention of egg allergy in infants (Dr. Fleischer):

  1. Natsume O, Kabashima S, Nakazato J, et al. Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial. Lancet 2017; 389:276.
  2. Palmer DJ, Sullivan TR, Gold MS, et al. Randomized controlled trial of early regular egg intake to prevent egg allergy. J Allergy Clin Immunol 2016.
  3. Wei-Liang Tan J, Valerio C, Barnes EH, et al. A randomized trial of egg introduction from 4 months of age in infants at risk for egg allergy. J Allergy Clin Immunol 2016.
  4. Bellach J, Schwarz V, Ahrens B, et al. Randomized placebo-controlled trial of hen's egg consumption for primary prevention in infants. J Allergy Clin Immunol 2016.

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Barbara Goff, MD Consultant/Advisory Boards: Roche Diagnostics [Biomarkers for ovarian cancer (HE4)]. Employment (Spouse): Lilly [General oncology (Gemcitabine, pemetrexed)] - No relevant conflict on topics.

David M Fleischer, MD Grant/Research/Clinical Trial Support: Monsanto Company [Food allergy]; Nestle Nutrition Institute [Food allergy]; DBV Technologies [Food allergies (Electrostatic immunotherapy patch)]; Aimmune Therapeutics [Food allergies (oral immunotherapy)]. Speaker's Bureau: Nestle Nutrition Institute [Food allergy]. Consultant/Advisory Boards: NIAID Coordinating Committee and Expert Panel, Update to the Food Allergy Guidelines, Prevention of Peanut Allergy [Food allergy]; Medical Advisory Board for the Food Allergy & Anaphylaxis Connection Team (FAACT) [Food allergy]; Medical Advisory Board for FARE [Food allergy]; Medical Advisory Council for the National Peanut Board [Food allergy]; DBV Technologies [Food allergy]’; Aimmune Therapeutics [Food allergy]; Intrommune Therapeutics [Food allergy]; Kaleo Pharma [Food allergy].

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Syncope and pulmonary embolus; Treatment of vulvovaginal atrophy

Date Released: 2月 8 2017

This episode features Dr. Jess Mandel, discussing the prevalence of pulmonary embolism in patients hospitalized for syncope (starts at 00:54); and Dr. Robert Barbieri, discussing the potential role for a new topical drug, prasterone (DHEA), in the treatment of genitourinary syndrome of menopause (starts at 11:44). Dr. Nancy Sokol hosts.

Listen to the full podcast by pressing the Play Button below, or jump to the segment on syncope and pulmonary embolus, or the segment on treatment of vulvovaginal atrophy.

Dr. MandelDr. Jess Mandel is a Professor of Clinical Medicine at the University of California San Diego.
Dr. BarbieriDr. Robert Barbieri is a Professor of Obstetrics, Gynecology, and Reproductive Biology at Harvard Medical School.

Segment on syncope and pulmonary embolus (Dr. Mandel):

  1. Prandoni P, Lensing AW, Prins MH, et al. Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope. N Engl J Med 2016; 375:1524.

Segment on treatment of vulvovaginal atrophy (Dr. Barbieri):

  1. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm529641.htm (Accessed on November 18, 2016).
  2. Labrie F, Derogatis L, Archer DF, et al. Effect of Intravaginal Prasterone on Sexual Dysfunction in Postmenopausal Women with Vulvovaginal Atrophy. J Sex Med 2015; 12:2401.

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Jess Mandel, MD Nothing to disclose

Robert L Barbieri, MD Nothing to disclose

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Severe asymptomatic hypertension; Endovascular vs. open abdominal aneurysm repair

Date Released: 1月 25 2017

In this episode, Dr. William Elliott discusses management of hypertensive urgency (starts at 00:50); and Dr. John Eidt discusses a comparison of long-term outcomes following endovascular and open surgical repair of an asymptomatic abdominal aneurysm (starts at 17:09). Dr. Nancy Sokol hosts.

Listen to the full podcast by pressing the Play Button below, or jump to the segment on severe asymptomatic hypertension, or the segment on endovascular vs. open abdominal aneurysm repair.

Dr. ElliottDr. William Elliott is a Professor of Preventive Medicine and Internal Medicine and Chair of the Department of Biomedical Sciences at the Pacific Northwest University of Health Science in Washington State.
Dr. EidtDr. John Eidt is a Professor of Surgery at Texas A&M Health Science Center and Vice Chair of Surgery at Baylor University Medical Center in Dallas, TX.

Segment on severe asymptomatic hypertension (Dr. Elliott):

  1. Patel KK, Young L, Howell EH, et al. Characteristics and Outcomes of Patients Presenting With Hypertensive Urgency in the Office Setting. JAMA Intern Med 2016; 176:981.

Segment on endovascular vs. open abdominal aneurysm repair (Dr. Eidt):

  1. Patel R, Sweeting MJ, Powell JT, et al. Endovascular versus open repair of abdominal aortic aneurysm in 15-years' follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1): a randomised controlled trial. Lancet 2016; 388:2366.
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William J Elliott, MD, PhD Consultant/Advisory Board: Novartis [Hypertension]. Other Financial Interest: Elsevier; Springer [Hypertension (book, journal)].

John F Eidt, MD Nothing to disclose

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Overdiagnosis of breast cancer with mammography

Date Released: 1月 12 2017

This episode features Dr. Joann Elmore, discussing the UpToDate What’s New topic on the overdiagnosis of breast cancer with mammography. Dr. Sandy Falk hosts.

Dr. ElmoreDr. Joann Elmore is a Professor of Medicine at the University of Washington School of Medicine.

Segment on overdiagnosis of breast cancer with mammography (Dr. Elmore):

  1. Welch HG, Prorok PC, O'Malley AJ, Kramer BS. Breast-Cancer Tumor Size, Overdiagnosis, and Mammography Screening Effectiveness. N Engl J Med 2016; 375:1438.

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Joann G Elmore, MD, MPH Nothing to disclose

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