Clinical Podcasts

UpToDate faculty discuss important “What’s New” and “Practice Changing UpDates”, based on recent medical journal articles, in our clinical podcasts. Our contributors are recognized physician leaders in their fields and offer their expertise regarding each update and its impact on clinical practice. Each clinical podcast includes the most current clinical information available as of the release date listed.

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Choice of influenza vaccines for 2016-2017 season; Complications of dopamine agonists for RLS

Date Released: Oct 12 2016

This episode features Dr. Martin Hirsch discussing choice of influenza vaccines for the 2016-17 season in the northern hemisphere (starts at 00:35); and Dr. Alon Avidan discussing the diagnosis and management of augmentation, a condition seen in patients with restless legs syndrome who have been treated with dopamine agonists (starts at 13:37). Dr. Nancy Sokol hosts.

Listen to the full podcast by pressing the Play Button below, or jump to the segment on choice of influenza vaccines for 2016-2017 season or the segment on complications of dopamine agonists for RLS.

Dr. HirschDr. Martin Hirsch is Professor of Medicine at the Harvard Medical School, Professor of Infectious Diseases and Immunology at the Harvard School of Public Health, and Senior Physician in Infectious Diseases at the Massachusetts General Hospital in Boston.
Dr. AvidanDr. Alon Avidan is Professor of Neurology at the David Geffen School of Medicine at UCLA and Director of the UCLA Sleep Disorders Center.

Segment on influenza vaccines (Dr. Hirsch):

  1. Centers for Disease Control and Prevention. ACIP votes down use of LAIV for 2016-2017 flu season. (Accessed on June 24, 2016).
  2. Hawkes N. UK stands by nasal flu vaccine for children as US doctors are told to stop using it. BMJ 2016; 353:i3546.
  3. AstraZeneca provides update on Flumist quadrivalent vaccine in the US for the 2016-2017 influenza season. (Accessed on June 27, 2016).
  4. Influenza vaccine effectiveness (VE) in adults and children in primary care in the UK: provisional end-of-season results 2015-2016. (Accessed on June 27, 2016).
  5. Seasonal childhood influenza vaccinations. Experiences from Finland. (Accessed on June 27, 2016).
Segment on restless legs syndrome (Dr. Avidan):
  1. Garcia-Borreguero D, Silber MH, Winkelman JW, et al. Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation. Sleep Med 2016; 21:1.


Martin S Hirsch, MD Nothing to disclose

Alon Avidan, MD Speaker's Bureau: Xenoport [Restless legs syndrome (Horizant)]; Merck [Insomnia (Suvorexant)].


Sofosbuvir-velpatasvir for chronic HCV infection; Neonatal phototherapy & risk of childhood cancer

Date Released: Sep 28 2016

This episode features Dr. Adrian Di Bisceglie discussing a Practice Changing UpDate related to sofosbuvir-velpatasvir for treatment of chronic HCV infection (starts at 00:51); and Dr. Vinod Bhutani discussing neonatal phototherapy and risk of childhood cancer (starts at 14:50). Dr. Nancy Sokol hosts.

Listen to the full podcast by pressing the Play Button below, or jump to the segment on sofosbuvir-velpatasvir for treatment of chronic HCV infection or the segment on neonatal phototherapy and risk of childhood cancer.

Dr. Di BisceglieDr. Adrian Di Bisceglie is Professor of Internal Medicine, Chairman of the Department of Internal Medicine, and Chief of Hepatology in the St. Louis University School of Medicine.
Dr. BhutaniDr. Vinod Bhutani is Professor of Pediatrics at Stanford University School of Medicine.

Segment on chronic HCV infection (Dr. Di Bisceglie):

  1. Feld JJ, Jacobson IM, Hézode C, et al. Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection. N Engl J Med 2015; 373:2599.
  2. Everson GT, Towner WJ, Davis MN, et al. Sofosbuvir With Velpatasvir in Treatment-Naive Noncirrhotic Patients With Genotype 1 to 6 Hepatitis C Virus Infection: A Randomized Trial. Ann Intern Med 2015; 163:818.
  3. Pianko S, Flamm SL, Shiffman ML, et al. Sofosbuvir Plus Velpatasvir Combination Therapy for Treatment-Experienced Patients With Genotype 1 or 3 Hepatitis C Virus Infection: A Randomized Trial. Ann Intern Med 2015; 163:809.

Segment on neonatal phototherapy (Dr. Bhutani):

  1. Newman TB, Wickremasinghe AC, Walsh EM, et al. Retrospective Cohort Study of Phototherapy and Childhood Cancer in Northern California. Pediatrics 2016; 137.
  2. Wickremasinghe AC, Kuzniewicz MW, Grimes BA, et al. Neonatal Phototherapy and Infantile Cancer. Pediatrics 2016; 137.


Adrian M Di Bisceglie, MD Grant/Research/Clinical Trial Support: AbbVie [therapy of hepatitis C (ombitasvir, paritaprevir, dasabuvir )]; Bristol-Myers Squibb [therapy of hepatitis C (daclatasvir)]; Gilead [therapy of hepatitis C (sofosbuvir, ledipasvir)]. Consultant/Advisory Board: AbbVie [therapy of hepatitis C (ombitasvir, paritaprevir, dasabuvir )]; Bristol-Myers Squibb [therapy of hepatitis C (daclatasvir)]; Gilead [therapy of hepatitis C (sofosbuvir, ledipasvir)].

Vinod K Bhutani, MD, FAAP Nothing to disclose


Duration of adjuvant endocrine therapy for breast cancer; Treatment for binge eating disorder

Date Released: Sep 14 2016

This episode features Dr. Harold Burstein discussing a Practice Changing Update related to the duration of adjuvant hormone therapy for non-metastatic, post-menopausal breast cancer (starts at 01:01); and Dr. Joel Yager discussing a recent systematic review of treatment for binge eating disorder (starts at 15:04). Dr. Nancy Sokol hosts.

Dr. BursteinDr. Harold Burstein is Associate Professor of Medicine at the Harvard Medical School and a medical oncologist at the Dana Farber Cancer Institute and Brigham and Women’s Hospital in Boston, MA.
Dr. YagerDr. Joel Yager is Professor of Psychiatry at the University of Colorado School of Medicine.

Segment on adjuvant endocrine therapy for breast cancer (Dr. Burstein):

  1. Goss PE, Ingle JN, Pritchard KI, et al. Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years. N Engl J Med 2016; 375:209

Segment on binge eating disorder (Dr. Yager):

  1. Brownley KA, Berkman ND, Peat CM, et al. Binge-Eating Disorder in Adults: A Systematic Review and Meta-analysis. Ann Intern Med 2016.


Harold Burstein, MD, PhD Nothing to disclose

Joel Yager, MD Nothing to disclose


Sexual dysfunction in women; Pediatric gastroenteritis; Childhood obesity

Date Released: Aug 11 2016

In this episode, Dr. Jan Shifren discusses flibanserin for treatment of sexual dysfunction in women (starts at 01:13); Dr. Stephen Freedman discusses use of diluted apple juice for hydration in children with mild gastroenteritis (starts at 11:31); and Dr. Kathleen Motil discusses the association between obesity in adolescence and cardiovascular mortality in adulthood (starts at 20:53). Dr. April Eichler hosts.

Dr. ShifrenDr. Jan Shifren is Associate Professor of Obstetrics, Gynecology, and Reproductive Biology at Harvard Medical School and director of the Midlife Women’s Health Center at the Massachusetts General Hospital.
Dr. FreedmanDr. Stephen Freedman is Associate Professor of Pediatrics at Alberta Children’s Hospital and the University of Calgary.
Dr. MotilDr. Kathleen Motil is Professor of Pediatrics at Baylor College of Medicine.

Segment on sexual dysfunction in women (Dr. Shifren):

  1. Jaspers L, Feys F, Bramer WM, et al. Efficacy and Safety of Flibanserin for the Treatment of Hypoactive Sexual Desire Disorder in Women: A Systematic Review and Meta-analysis. JAMA Intern Med 2016; 176:453.

Segment on pediatric gastroenteritis (Dr. Freedman):

  1. Freedman SB, Willan AR, Boutis K, Schuh S. Effect of Dilute Apple Juice and Preferred Fluids vs Electrolyte Maintenance Solution on Treatment Failure Among Children With Mild Gastroenteritis: A Randomized Clinical Trial. JAMA 2016; 315:1966.

Segment on childhood obesity (Dr. Motil):

  1. Twig G, Yaniv G, Levine H, et al. Body-Mass Index in 2.3 Million Adolescents and Cardiovascular Death in Adulthood. N Engl J Med 2016; 374:2430.


Jan L Shifren, MD Consultant/Advisory Boards: New England Research Institutes [Epidemiological research related to genitourinary syndrome of menopause].

Stephen Freedman, MDCM, MSc Grant/Research/Clinical Trial Support: Novartis [antiemetics (ondansetron)].

Kathleen J Motil, MD, PhD Nothing to disclose.